Monoamine Transporter as a Drug Action Essay -- Biology, Neurotransmit

Neurotransmitters are chemicals; signals are transmitted from neuron to the target cell via a synapse through neurotransmitters. Neurotransmitters are associated in the synaptic vesicles congregated in the presynaptic membrane and are released in the synaptic cleft, In the synaptic cleft they attach to the receptors in the postsynaptic membrane.(1)Monoamine transporters are proteins which are found on nerve terminals of noradrenegenic,serotonergic and dopaminergic neurons. They are also part of sodium dependent transporters and have a key role in terminating the released neurotransmitters action in the synaptic cleft. In addition Transporter proteins are important in assimilating monoaminergic innervations as well as being the main target molecules for numerous amount of antidepressive drugs and substances for abuse. Monoamine transporters consists vesicular monoamine transporters (VMAT) and plasma membrane. Monoamine is carried in to the vesicles by the latter non-selectively and do pamine, nor adrenaline and serotonin is transported into vesicles by Na+/Cl- and selectively former. Monoamine transportation into the cytoplasm is inhibited when antiepileptic drugs for instance SSRI is attached to nor adrenaline transport (NET) or Dopamine transporter (DAT) and serotonin transport (SERT). Thus the monoamine level increases in the synaptic cleft. Monoamine transporters are the site for drug action,(2)Affective disease such as schizophrenia or Parkinson’s disease may be involved due to functional changes in the transporters. The neurotransmitter transporters are proven to be most important targets for CNS drug discovery,(3)mainly for antidepressant drugs. Antidepressants act as a inhibitors of monoamine transporters. Serotonin se... ...ion and the evidence proved in this study was due to low concentration of homovanillic acid which is a metabolite of dopamine(6).Dopamine agonists such as ropinirole,bromocriptine shows antidepressant characteristics.Amineptine is a TCA derivative which also blocks the reuptake of dopamine and exhibit activity of noradrenergic and serotonergic.Most of the existing antidepressants seem to exhibit a similar efficacy in the general treatment of depression, however, antidepressants that have different profiles of action may target particular symptoms within the depressive syndrome more effectively. In such cases, the treatment provided could be accurately focused towards the predominant or driving symptomatology for a specific patient. Studies have shown that this method of treatment has the potential of improving the rate of response and remission.(6)